Cellular alterations associated with therapy-induced senescence

A large amount of apparently senescent tumor cells are observed after chemo/radio therapy, as indicated by ß-Gal staining in HeLa and MCF7 long-term cultures. The observation of ß-Gal positive cells indicates the coexistence of sub-populations of cells with possible different behaviors in terms of resistance to therapeutic agents. In both camptothecin-treated and...

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