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Graphene: Ultimate tech for cell analysis and tissue imaging
The intensity changes of lipid species may be explained by the presence of different cell types in the inner (non-proliferative or dead cells) and outer (proliferative cells) regions in spheroids, which had different types of metabolism.
![](https://sp-ao.shortpixel.ai/client/to_webp,q_lossy,ret_img,w_300,h_252/https://www.crimson-project.eu/wp-content/uploads/2021/11/Immagine-poster-4_1-300x252.png)
![](https://sp-ao.shortpixel.ai/client/to_webp,q_lossy,ret_img,w_300,h_275/https://www.crimson-project.eu/wp-content/uploads/2021/11/Immagine-poster-4_2-300x275.png)
K-means based clustering analysis
![](https://sp-ao.shortpixel.ai/client/to_webp,q_lossy,ret_img,w_715,h_395/https://www.crimson-project.eu/wp-content/uploads/2021/11/Immagine-poster-4_3.png)
The distribution pattern of PI 36:2 at m/z 861.045 was up-regulated in the inner region of the spheroids with AUC value of 0.903.
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