Graphene: Ultimate tech for cell analysis and tissue imaging

The intensity changes of lipid species may be explained by the presence of different cell types in the inner (non-proliferative or dead cells) and outer (proliferative cells) regions in spheroids, which had different types of metabolism.

K-means based clustering analysis 

The distribution pattern of PI 36:2 at m/z 861.045 was up-regulated in the inner region of the spheroids with AUC value of 0.903.