Complete digestion of a cell-in-cell structure after chemotherapy
Camptothecin treatment of MCF7 cells induces either a classic senescent phenotype or the formation of cell-in-cell structures (CIC).
After the internalization of a neighboring cell, MCF7 cells develop a digestive vacuole (see arrow in Fig.1). The vacuole undergoes sequential steps of maturation, culminating in the degradation of the internalized cell (Fig. 2).