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Complete digestion of a cell-in-cell structure after chemotherapy
Camptothecin treatment of MCF7 cells induces either a classic senescent phenotype or the formation of cell-in-cell structures (CIC).
After the internalization of a neighboring cell, MCF7 cells develop a digestive vacuole (see arrow in Fig.1). The vacuole undergoes sequential steps of maturation, culminating in the degradation of the internalized cell (Fig. 2).
![](https://sp-ao.shortpixel.ai/client/to_webp,q_lossy,ret_img,w_469,h_449/https://www.crimson-project.eu/wp-content/uploads/2021/10/int_post2_1.png)
Fig. 1. Representative time lapse image sequence of MCF7 cells treated with 250 nM camptothecin. The yellow arrows indicate the vacuole inside an individual cell.
![](https://sp-ao.shortpixel.ai/client/to_webp,q_lossy,ret_img,w_320,h_240/https://www.crimson-project.eu/wp-content/uploads/2021/10/int_post3_2.png)
Fig. 2. Confocal microscopy of a MCF7 cell treated with 250nM camptothecin after cell ingestion (red: LC3-B; blue: DAPI).
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