Senescent cancer cells take up and digest neighboring cells

Cell-in-cell structures are observed in tumor tissues in vivo and are generally associated with poor prognosis for the patient, making their identification and characterization compelling.

The term cell-in-cell, morphologically, refers to the presence of one cell within another living one. Crucially, senescent cells that eat their neighbours survive better than those that do not.

Here, we show a chemotherapy-induced senescent cell which has a large vesicle within it evidently originated from the internalization of another vital, neighboring tumor cell.

Cells were labeled live with Lysotracker after being treated with a chemotherapeutic compound and analyzed by fluorescence microscopy.
Image processing was performed with ImageJ software.